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KMID : 0921620190490020053
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Journal of Bacteriology and Virology
2019 Volume.49 No. 2 p.53 ~ p.58
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Association Between Toxin-antitoxin Systems on Plasmids and Persister Formation in CTX-15-producing Klebsiella pneumoniae ST11 Isolates
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Chung Eun-Seon
Kim So-Yeon
Ko Kwan-Soo
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Abstract
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We investigated the effect of toxin-antitoxin (TA) systems in blaCTX-M-15-bearing plasmids of Klebsiella pneumoniae on persister formation. The persister formation rate was notably high in transconjugants in plasmids bearing TA system than the transconjugants in plasmids bearing no TA systems. Activation of relA and spoT expression was higher in transconjugants with plasmids bearing TA systems. Thus, TA systems in plasmids may contribute to the maintenance of blaCTX-M-15-bearing plasmids and host survival via persister formation.
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KEYWORD
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persister, toxin-antitoxin (TA) system, CTX-M-15, ppGpp
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